Pentraxin-related protein PTX3 (PTX3)

About Pentraxin-related protein PTX3

Pentraxin-related protein PTX3 (PTX3) is a protein from Homo sapiens identified by UniProt accession P26022, 381 residues long. MolForge cross-references it against 0 known binders and 712 disease associations.

Target properties

Protein name	Pentraxin-related protein PTX3
UniProt accession	P26022
Gene	PTX3
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (712)

Diseases linked to this target (Open Targets).

pentraxin-related protein PTX3 measurement · score 0.14
polycystic ovary syndrome · score 0.12
neuroticism measurement · score 0.12
neoplasm · score 0.12
Sepsis · score 0.11
COVID-19 · score 0.11
hepatocellular carcinoma · score 0.11
coronary artery disease · score 0.11
Female infertility due to fertilization defect · score 0.11
hair shape measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26022-F1	alphafold	PREDICTED	76.72	—

Amino-acid sequence (381 residues)

MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCACG QEHSEWDKLF IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA RPCAPGAPAE ARLTSALDEL LQATRDAGRR LARMEGAEAQ RPEEAGRALA AVLEELRQTR ADLHAVQGWA ARSWLPAGCE TAILFPMRSK KIFGSVHPVR PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL SYQSIVFVVG GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards