Moesin (MSN)

About Moesin

Moesin (MSN) is a protein from Homo sapiens identified by UniProt accession P26038, 577 residues long. MolForge cross-references it against 0 known binders and 575 disease associations.

Target properties

Protein name	Moesin
UniProt accession	P26038
Gene	MSN
Organism	Homo sapiens
Length	577 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (575)

Diseases linked to this target (Open Targets).

combined immunodeficiency due to moesin deficiency · score 0.71
cancer · score 0.47
combined immunodeficiency · score 0.46
Combined immunodeficiency · score 0.46
liver disease · score 0.32
anaplastic large cell lymphoma · score 0.28
neurodegenerative disease · score 0.28
oral squamous cell carcinoma · score 0.21
lung adenocarcinoma · score 0.20
neoplasm · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26038-F1	alphafold	PREDICTED	86.39	—

Amino-acid sequence (577 residues)

MPKTISVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWFFGLQYQ DTKGFSTWLK LNKKVTAQDV RKESPLLFKF RAKFYPEDVS EELIQDITQR LFFLQVKEGI LNDDIYCPPE TAVLLASYAV QSKYGDFNKE VHKSGYLAGD KLLPQRVLEQ HKLNKDQWEE RIQVWHEEHR GMLREDAVLE YLKIAQDLEM YGVNYFSIKN KKGSELWLGV DALGLNIYEQ NDRLTPKIGF PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQMER AMLENEKKKR EMAEKEKEKI EREKEELMER LKQIEEQTKK AQQELEEQTR RALELEQERK RAQSEAEKLA KERQEAEEAK EALLQASRDQ KKTQEQLALE MAELTARISQ LEMARQKKES EAVEWQQKAQ MVQEDLEKTR AELKTAMSTP HVAEPAENEQ DEQDENGAEA SADLRADAMA KDRSEEERTT EAEKNERVQK HLKALTSELA NARDESKKTA NDMIHAENMR LGRDKYKTLR QIRQGNTKQR IDEFESM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards