About Probable ATP-dependent RNA helicase DDX6
Probable ATP-dependent RNA helicase DDX6 (DDX6) is a protein
from Homo sapiens identified by UniProt accession
P26196, 483 residues long.
MolForge cross-references it against 0 known binders and
205 disease associations.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX6 |
|---|
| UniProt accession | P26196 |
|---|
| Gene | DDX6 |
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| Organism | Homo sapiens |
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| Length | 483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (205)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with impaired language and dysmorphic facies · score 0.60
- Intellectual disability · score 0.58
- neurodegenerative disease · score 0.46
- Global developmental delay · score 0.37
- lung carcinoma · score 0.37
- bile duct carcinoma · score 0.37
- disease of genitourinary system · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- Generalized hypotonia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26196-F1 | alphafold | PREDICTED | 84.09 | — |
Amino-acid sequence (483 residues)
MSTARTENPV IMGLSSQNGQ LRGPVKPTGG PGGGGTQTQQ QMNQLKNTNT INNGTQQQAQ SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED YCLKRELLMG IFEMGWEKPS PIQEESIPIA LSGRDILARA KNGTGKSGAY LIPLLERLDL KKDNIQAMVI VPTRELALQV SQICIQVSKH MGGAKVMATT GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVDHV QMIVLDEADK LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL AKKISQLGYS CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI QAVNVVINFD FPKLAETYLH RIGRSGRFGH LGLAINLITY DDRFNLKSIE EQLGTEIKPI PSNIDKSLYV AEYHSEPVED EKP
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