About Paired box protein Pax-6
Paired box protein Pax-6 (PAX6) is a protein
from Homo sapiens identified by UniProt accession
P26367, 422 residues long.
MolForge cross-references it against 0 known binders and
763 disease associations.
Target properties
| Protein name | Paired box protein Pax-6 |
|---|
| UniProt accession | P26367 |
|---|
| Gene | PAX6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 422 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (763)
Diseases linked to this target (Open Targets).
- Peters anomaly · score 0.81
- aniridia · score 0.76
- foveal hypoplasia 1 · score 0.75
- Foveal hypoplasia - presenile cataract · score 0.71
- isolated optic nerve hypoplasia · score 0.71
- coloboma of optic nerve · score 0.71
- Aniridia · score 0.69
- coloboma, ocular, autosomal dominant · score 0.69
- autosomal dominant keratitis · score 0.68
- isolated aniridia · score 0.68
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26367-F1 | alphafold | PREDICTED | 68.43 | — |
Amino-acid sequence (422 residues)
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG VSVPVQVPGS EPDMSQYWPR LQ
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