Splicing factor U2AF 65 kDa subunit (U2AF2)

About Splicing factor U2AF 65 kDa subunit

Splicing factor U2AF 65 kDa subunit (U2AF2) is a protein from Homo sapiens identified by UniProt accession P26368, 475 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Splicing factor U2AF 65 kDa subunit
UniProt accession	P26368
Gene	U2AF2
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

Neurodevelopmental disorder · score 0.58
Intellectual disability · score 0.46
acute myeloid leukemia · score 0.36
neurodegenerative disease · score 0.35
genetic disorder · score 0.33
leukodystrophy · score 0.26
chronic lymphocytic leukemia · score 0.16
non-small cell lung carcinoma · score 0.08
neoplasm · score 0.06
lumbar disc degeneration · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26368-F1	alphafold	PREDICTED	73.21	—

Amino-acid sequence (475 residues)

MSDFDEFERQ LNENKQERDK ENRHRKRSHS RSRSRDRKRR SRSRDRRNRD QRSASRDRRR RSKPLTRGAK EEHGGLIRSP RHEKKKKVRK YWDVPPPGFE HITPMQYKAM QAAGQIPATA LLPTMTPDGL AVTPTPVPVV GSQMTRQARR LYVGNIPFGI TEEAMMDFFN AQMRLGGLTQ APGNPVLAVQ INQDKNFAFL EFRSVDETTQ AMAFDGIIFQ GQSLKIRRPH DYQPLPGMSE NPSVYVPGVV STVVPDSAHK LFIGGLPNYL NDDQVKELLT SFGPLKAFNL VKDSATGLSK GYAFCEYVDI NVTDQAIAGL NGMQLGDKKL LVQRASVGAK NATLVSPPST INQTPVTLQV PGLMSSQVQM GGHPTEVLCL MNMVLPEELL DDEEYEEIVE DVRDECSKYG LVKSIEIPRP VDGVEVPGCG KIFVEFTSVF DCQKAMQGLT GRKFANRVVV TKYCDPDSYH RRDFW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards