About Rab proteins geranylgeranyltransferase component A 2
Rab proteins geranylgeranyltransferase component A 2 (CHML) is a protein
from Homo sapiens identified by UniProt accession
P26374, 656 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Rab proteins geranylgeranyltransferase component A 2 |
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| UniProt accession | P26374 |
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| Gene | CHML |
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| Organism | Homo sapiens |
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| Length | 656 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- drug use measurement · score 0.15
- hepatocellular carcinoma · score 0.08
- Miyoshi myopathy · score 0.07
- self reported educational attainment · score 0.07
- mathematical ability · score 0.07
- non-small cell lung carcinoma · score 0.06
- lung adenocarcinoma · score 0.03
- neoplasm · score 0.03
- choroideremia · score 0.02
- multiple myeloma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26374-F1 | alphafold | PREDICTED | 79.40 | — |
Amino-acid sequence (656 residues)
MADNLPTEFD VVIIGTGLPE SILAAACSRS GQRVLHIDSR SYYGGNWASF SFSGLLSWLK EYQQNNDIGE ESTVVWQDLI HETEEAITLR KKDETIQHTE AFCYASQDME DNVEEIGALQ KNPSLGVSNT FTEVLDSALP EESQLSYFNS DEMPAKHTQK SDTEISLEVT DVEESVEKEK YCGDKTCMHT VSDKDGDKDE SKSTVEDKAD EPIRNRITYS QIVKEGRRFN IDLVSKLLYS QGLLIDLLIK SDVSRYVEFK NVTRILAFRE GKVEQVPCSR ADVFNSKELT MVEKRMLMKF LTFCLEYEQH PDEYQAFRQC SFSEYLKTKK LTPNLQHFVL HSIAMTSESS CTTIDGLNAT KNFLQCLGRF GNTPFLFPLY GQGEIPQGFC RMCAVFGGIY CLRHKVQCFV VDKESGRCKA IIDHFGQRIN AKYFIVEDSY LSEETCSNVQ YKQISRAVLI TDQSILKTDL DQQTSILIVP PAEPGACAVR VTELCSSTMT CMKDTYLVHL TCSSSKTARE DLESVVKKLF TPYTETEINE EELTKPRLLW ALYFNMRDSS GISRSSYNGL PSNVYVCSGP DCGLGNEHAV KQAETLFQEI FPTEEFCPPP PNPEDIIFDG DDKQPEAPGT NNVVMAKLES SEESKNLESP EKHLQN
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