About Ciliary neurotrophic factor
Ciliary neurotrophic factor (CNTF) is a protein
from Homo sapiens identified by UniProt accession
P26441, 200 residues long.
MolForge cross-references it against 0 known binders and
258 disease associations.
Target properties
| Protein name | Ciliary neurotrophic factor |
|---|
| UniProt accession | P26441 |
|---|
| Gene | CNTF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 200 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (258)
Diseases linked to this target (Open Targets).
- thyroid gland adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.21
- monocyte count · score 0.13
- cutaneous melanoma · score 0.10
- breast adenocarcinoma · score 0.09
- experimental autoimmune encephalomyelitis · score 0.09
- Obesity · score 0.08
- amyotrophic lateral sclerosis · score 0.07
- open-angle glaucoma · score 0.07
- body height · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26441-F1 | alphafold | PREDICTED | 85.10 | — |
Amino-acid sequence (200 residues)
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
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