Protein S100-A4 (S100A4)

About Protein S100-A4

Protein S100-A4 (S100A4) is a protein from Homo sapiens identified by UniProt accession P26447, 101 residues long. MolForge cross-references it against 0 known binders and 493 disease associations.

Target properties

Protein name	Protein S100-A4
UniProt accession	P26447
Gene	S100A4
Organism	Homo sapiens
Length	101 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (493)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.35
Alzheimer disease · score 0.35
Parkinson disease · score 0.35
lysosomal storage disease · score 0.35
neurodegenerative disease · score 0.35
blood protein measurement · score 0.17
pulse pressure measurement · score 0.14
neoplasm · score 0.12
prostate carcinoma · score 0.11
prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26447-F1	alphafold	PREDICTED	86.41	—

Amino-acid sequence (101 residues)

MACPLEKALD VMVSTFHKYS GKEGDKFKLN KSELKELLTR ELPSFLGKRT DEAAFQKLMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGFPDKQPRK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards