About Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT1) is a protein
from Homo sapiens identified by UniProt accession
P26572, 445 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| UniProt accession | P26572 |
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| Gene | MGAT1 |
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| Organism | Homo sapiens |
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| Length | 445 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- Parkinson disease · score 0.34
- multiple sclerosis · score 0.34
- Alzheimer disease · score 0.34
- lysosomal storage disease · score 0.34
- apolipoprotein A 1 measurement · score 0.31
- neuroinflammatory disorder · score 0.30
- high density lipoprotein cholesterol measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26572-F1 | alphafold | PREDICTED | 88.55 | — |
Amino-acid sequence (445 residues)
MLKKQSAGLV LWGAILFVAW NALLLLFFWT RPAPGRPPSV SALDGDPASL TREVIRLAQD AEVELERQRG LLQQIGDALS SQRGRVPTAA PPAQPRVPVT PAPAVIPILV IACDRSTVRR CLDKLLHYRP SAELFPIIVS QDCGHEETAQ AIASYGSAVT HIRQPDLSSI AVPPDHRKFQ GYYKIARHYR WALGQVFRQF RFPAAVVVED DLEVAPDFFE YFRATYPLLK ADPSLWCVSA WNDNGKEQMV DASRPELLYR TDFFPGLGWL LLAELWAELE PKWPKAFWDD WMRRPEQRQG RACIRPEISR TMTFGRKGVS HGQFFDQHLK FIKLNQQFVH FTQLDLSYLQ REAYDRDFLA RVYGAPQLQV EKVRTNDRKE LGEVRVQYTG RDSFKAFAKA LGVMDDLKSG VPRAGYRGIV TFQFRGRRVH LAPPLTWEGY DPSWN
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