About High mobility group protein B2
High mobility group protein B2 (HMGB2) is a protein
from Homo sapiens identified by UniProt accession
P26583, 209 residues long.
MolForge cross-references it against 0 known binders and
292 disease associations.
Target properties
| Protein name | High mobility group protein B2 |
|---|
| UniProt accession | P26583 |
|---|
| Gene | HMGB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 209 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (292)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.24
- low grade glioma · score 0.23
- endometrial cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.12
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.09
- azoospermia · score 0.09
- IGA glomerulonephritis · score 0.08
- lung adenocarcinoma · score 0.08
- osteosarcoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26583-F1 | alphafold | PREDICTED | 77.58 | — |
Amino-acid sequence (209 residues)
MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG SKKKNEPEDE EEEEEEEDED EEEEDEDEE
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