About Polypyrimidine tract-binding protein 1
Polypyrimidine tract-binding protein 1 (PTBP1) is a protein
from Homo sapiens identified by UniProt accession
P26599, 557 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Polypyrimidine tract-binding protein 1 |
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| UniProt accession | P26599 |
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| Gene | PTBP1 |
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| Organism | Homo sapiens |
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| Length | 557 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (247)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.39
- hemoglobin measurement · score 0.38
- hematocrit · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.36
- serum alanine aminotransferase measurement · score 0.34
- reticulocyte count · score 0.33
- aspartate aminotransferase measurement · score 0.31
- erythrocyte count · score 0.31
- C-reactive protein measurement · score 0.30
- monocyte count · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26599-F1 | alphafold | PREDICTED | 70.53 | — |
Amino-acid sequence (557 residues)
MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD SRSAGVPSRV IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE MNTEEAANTM VNYYTSVTPV LRGQPIYIQF SNHKELKTDS SPNQARAQAA LQAVNSVQSG NLALAASAAA VDAGMAMAGQ SPVLRIIVEN LFYPVTLDVL HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS LDGQNIYNAC CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGAP GIISASPYAG AGFPPTFAIP QAAGLSVPNV HGALAPLAIP SAAAAAAAAG RIAIPGLAGA GNSVLLVSNL NPERVTPQSL FILFGVYGDV QRVKILFNKK ENALVQMADG NQAQLAMSHL NGHKLHGKPI RITLSKHQNV QLPREGQEDQ GLTKDYGNSP LHRFKKPGSK NFQNIFPPSA TLHLSNIPPS VSEEDLKVLF SSNGGVVKGF KFFQKDRKMA LIQMGSVEEA VQALIDLHNH DLGENHHLRV SFSKSTI
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