About Threonine--tRNA ligase 1, cytoplasmic
Threonine--tRNA ligase 1, cytoplasmic (TARS1) is a protein
from Homo sapiens identified by UniProt accession
P26639, 723 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Threonine--tRNA ligase 1, cytoplasmic |
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| UniProt accession | P26639 |
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| Gene | TARS1 |
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| Organism | Homo sapiens |
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| Length | 723 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- trichothiodystrophy · score 0.55
- body height · score 0.39
- vital capacity · score 0.33
- systolic blood pressure · score 0.33
- BMI-adjusted waist circumference · score 0.31
- forced expiratory volume · score 0.27
- appendicular lean mass · score 0.25
- lymphocyte percentage of leukocytes · score 0.23
- neutrophil percentage of leukocytes · score 0.22
- hypertension · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26639-F1 | alphafold | PREDICTED | 90.50 | — |
Amino-acid sequence (723 residues)
MFEEKASSPS GKMGGEEKPI GAGEEKQKEG GKKKNKEGSG DGGRAELNPW PEYIYTRLEM YNILKAEHDS ILAEKAEKDS KPIKVTLPDG KQVDAESWKT TPYQIACGIS QGLADNTVIA KVNNVVWDLD RPLEEDCTLE LLKFEDEEAQ AVYWHSSAHI MGEAMERVYG GCLCYGPPIE NGFYYDMYLE EGGVSSNDFS SLEALCKKII KEKQAFERLE VKKETLLAMF KYNKFKCRIL NEKVNTPTTT VYRCGPLIDL CRGPHVRHTG KIKALKIHKN SSTYWEGKAD METLQRIYGI SFPDPKMLKE WEKFQEEAKN RDHRKIGRDQ ELYFFHELSP GSCFFLPKGA YIYNALIEFI RSEYRKRGFQ EVVTPNIFNS RLWMTSGHWQ HYSENMFSFE VEKELFALKP MNCPGHCLMF DHRPRSWREL PLRLADFGVL HRNELSGALT GLTRVRRFQQ DDAHIFCAME QIEDEIKGCL DFLRTVYSVF GFSFKLNLST RPEKFLGDIE VWDQAEKQLE NSLNEFGEKW ELNSGDGAFY GPKIDIQIKD AIGRYHQCAT IQLDFQLPIR FNLTYVSHDG DDKKRPVIVH RAILGSVERM IAILTENYGG KWPFWLSPRQ VMVVPVGPTC DEYAQKVRQQ FHDAKFMADI DLDPGCTLNK KIRNAQLAQY NFILVVGEKE KISGTVNIRT RDNKVHGERT ISETIERLQQ LKEFRSKQAE EEF
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