Elongation factor 1-gamma (EEF1G)

About Elongation factor 1-gamma

Elongation factor 1-gamma (EEF1G) is a protein from Homo sapiens identified by UniProt accession P26641, 437 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Elongation factor 1-gamma
UniProt accession	P26641
Gene	EEF1G
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
cancer · score 0.47
BMI-adjusted waist-hip ratio · score 0.17
physical activity measurement · score 0.15
high density lipoprotein cholesterol measurement · score 0.12
endometrial cancer · score 0.11
forced expiratory volume · score 0.10
diet measurement · score 0.09
waist-hip ratio · score 0.09
BMI-adjusted waist circumference · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26641-F1	alphafold	PREDICTED	85.74	—

Amino-acid sequence (437 residues)

MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL RKFPAGKVPA FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS FADSDIVPPA STWVFPTLGI MHHNKQATEN AKEEVRRILG LLDAYLKTRT FLVGERVTLA DITVVCTLLW LYKQVLEPSF RQAFPNTNRW FLTCINQPQF RAVLGEVKLC EKMAQFDAKK FAETQPKKDT PRKEKGSREE KQKPQAERKE EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE DTLSVALPYF WEHFDKDGWS LWYSEYRFPE ELTQTFMSCN LITGMFQRLD KLRKNAFASV ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR KLDPGSEETQ TLVREYFSWE GAFQHVGKAF NQGKIFK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards