Phospholamban (PLN)

About Phospholamban

Phospholamban (PLN) is a protein from Homo sapiens identified by UniProt accession P26678, 52 residues long. MolForge cross-references it against 0 known binders and 265 disease associations.

Target properties

Protein name	Phospholamban
UniProt accession	P26678
Gene	PLN
Organism	Homo sapiens
Length	52 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (265)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy · score 0.71
familial isolated dilated cardiomyopathy · score 0.65
cardiomyopathy · score 0.53
intrinsic cardiomyopathy · score 0.50
Rare familial disorder with hypertrophic cardiomyopathy · score 0.50
Abnormality of the cardiovascular system · score 0.47
dilated cardiomyopathy · score 0.46
electrocardiography · score 0.38
QT interval · score 0.37
Arrhythmogenic right ventricular dysplasia · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26678-F1	alphafold	PREDICTED	81.90	—

Amino-acid sequence (52 residues)

MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards