NKG2-A/NKG2-B type II integral membrane protein…

About NKG2-A/NKG2-B type II integral membrane protein

NKG2-A/NKG2-B type II integral membrane protein (KLRC1) is a protein from Homo sapiens identified by UniProt accession P26715, 233 residues long. MolForge cross-references it against 0 known binders and 317 disease associations.

Target properties

Protein name	NKG2-A/NKG2-B type II integral membrane protein
UniProt accession	P26715
Gene	KLRC1
Organism	Homo sapiens
Length	233 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (317)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.31
monocyte count · score 0.28
mean corpuscular volume · score 0.27
reticulocyte count · score 0.27
head and neck squamous cell carcinoma · score 0.27
platelet count · score 0.25
erythrocyte count · score 0.25
mean reticulocyte volume · score 0.24
mean corpuscular hemoglobin · score 0.22
mean corpuscular hemoglobin concentration · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26715-F1	alphafold	PREDICTED	75.64	—

Amino-acid sequence (233 residues)

MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ DFQGNDKTYH CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NKG2-A/NKG2-B type II integral membrane protein (KLRC1)