NKG2-C type II integral membrane protein (KLRC2)

About NKG2-C type II integral membrane protein

NKG2-C type II integral membrane protein (KLRC2) is a protein from Homo sapiens identified by UniProt accession P26717, 231 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	NKG2-C type II integral membrane protein
UniProt accession	P26717
Gene	KLRC2
Organism	Homo sapiens
Length	231 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.34
monocyte count · score 0.34
serum alanine aminotransferase measurement · score 0.31
mean corpuscular hemoglobin concentration · score 0.29
monocyte percentage of leukocytes · score 0.29
mean corpuscular hemoglobin · score 0.28
erythrocyte count · score 0.27
platelet count · score 0.26
neutrophil percentage of leukocytes · score 0.23
red blood cell density measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26717-F1	alphafold	PREDICTED	73.53	—

Amino-acid sequence (231 residues)

MNKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NFSPNTRTQK ARHCGHCPEE WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards