About NKG2-D type II integral membrane protein
NKG2-D type II integral membrane protein (KLRK1) is a protein
from Homo sapiens identified by UniProt accession
P26718, 216 residues long.
MolForge cross-references it against 0 known binders and
531 disease associations.
Target properties
| Protein name | NKG2-D type II integral membrane protein |
|---|
| UniProt accession | P26718 |
|---|
| Gene | KLRK1 |
|---|
| Organism | Homo sapiens |
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| Length | 216 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (531)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.16
- neoplasm · score 0.12
- NKG2-D type II integral membrane protein measurement · score 0.12
- neutrophil percentage of leukocytes · score 0.12
- aspartate aminotransferase measurement · score 0.11
- hepatocellular carcinoma · score 0.11
- cancer · score 0.11
- platelet count · score 0.10
- monocyte count · score 0.10
- Systemic lupus erythematosus · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26718-F1 | alphafold | PREDICTED | 79.18 | — |
Amino-acid sequence (216 residues)
MGWIRGRRSR HSWEMSEFHN YNLDLKKSDF STRWQKQRCP VVKSKCRENA SPFFFCCFIA VAMGIRFIIM VTIWSAVFLN SLFNQEVQIP LTESYCGPCP KNWICYKNNC YQFFDESKNW YESQASCMSQ NASLLKVYSK EDQDLLKLVK SYHWMGLVHI PTNGSWQWED GSILSPNLLT IIEMQKGDCA LYASSFKGYI ENCSTPNTYI CMQRTV
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