Interleukin-3 receptor subunit alpha (IL3RA)

About Interleukin-3 receptor subunit alpha

Interleukin-3 receptor subunit alpha (IL3RA) is a protein from Homo sapiens identified by UniProt accession P26951, 378 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Interleukin-3 receptor subunit alpha
UniProt accession	P26951
Gene	IL3RA
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

acute myeloid leukemia · score 0.41
neoplasm · score 0.37
lymphoma · score 0.37
glioblastoma multiforme · score 0.30
breast adenocarcinoma · score 0.29
endometrial cancer · score 0.25
neurodegenerative disease · score 0.24
head and neck squamous cell carcinoma · score 0.23
gastric adenocarcinoma · score 0.12
myelodysplastic syndrome · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26951-F1	alphafold	PREDICTED	85.27	—

Amino-acid sequence (378 residues)

MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI ECVKDADYSM PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS GKPWAGAENL TCWIHDVDFL SCSWAVGPGA PADVQYDLYL NVANRRQQYE CLHYKTDAQG TRIGCRFDDI SRLSSGSQSS HILVRGRSAA FGIPCTDKFV VFSQIEILTP PNMTAKCNKT HSFMHWKMRS HFNRKFRYEL QIQKRMQPVI TEQVRDRTSF QLLNPGTYTV QIRARERVYE FLSAWSTPQR FECDQEEGAN TRAWRTSLLI ALGTLLALVC VFVICRRYLV MQRLFPRIPH MKDPIGDSFQ NDKLVVWEAG KAGLEECLVT EVQVVQKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards