About Ciliary neurotrophic factor receptor subunit alpha
Ciliary neurotrophic factor receptor subunit alpha (CNTFR) is a protein
from Homo sapiens identified by UniProt accession
P26992, 372 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Ciliary neurotrophic factor receptor subunit alpha |
|---|
| UniProt accession | P26992 |
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| Gene | CNTFR |
|---|
| Organism | Homo sapiens |
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| Length | 372 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- blood protein measurement · score 0.29
- heel bone mineral density · score 0.22
- lung adenocarcinoma · score 0.22
- adolescent idiopathic scoliosis · score 0.15
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- cutaneous melanoma · score 0.10
- breast adenocarcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26992-F1 | alphafold | PREDICTED | 82.52 | — |
Amino-acid sequence (372 residues)
MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LVSVPITLAL AAAAATASSL LI
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