About Beta-crystallin B3
Beta-crystallin B3 (CRYBB3) is a protein
from Homo sapiens identified by UniProt accession
P26998, 211 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Beta-crystallin B3 |
|---|
| UniProt accession | P26998 |
|---|
| Gene | CRYBB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- Anterior polar cataract · score 0.78
- early-onset non-syndromic cataract · score 0.52
- Developmental cataract · score 0.40
- early-onset nuclear cataract · score 0.37
- early-onset anterior polar cataract · score 0.37
- microphthalmia · score 0.34
- cataract · score 0.34
- protein measurement · score 0.23
- visual perception measurement · score 0.21
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26998-F1 | alphafold | PREDICTED | 86.72 | — |
Amino-acid sequence (211 residues)
MAEQHGAPEQ AAAGKSHGDL GGSYKVILYE LENFQGKRCE LSAECPSLTD SLLEKVGSIQ VESGPWLAFE SRAFRGEQFV LEKGDYPRWD AWSNSRDSDS LLSLRPLNID SPHHKLHLFE NPAFSGRKME IVDDDVPSLW AHGFQDRVAS VRAINGTWVG YEFPGYRGRQ YVFERGEYRH WNEWDASQPQ LQSVRRIRDQ KWHKRGRFPS S
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