About Activin receptor type-2A
Activin receptor type-2A (ACVR2A) is a protein
from Homo sapiens identified by UniProt accession
P27037, 513 residues long.
MolForge cross-references it against 0 known binders and
456 disease associations.
Target properties
| Protein name | Activin receptor type-2A |
|---|
| UniProt accession | P27037 |
|---|
| Gene | ACVR2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 513 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (456)
Diseases linked to this target (Open Targets).
- colorectal adenocarcinoma · score 0.47
- tibia fracture · score 0.46
- neurodegenerative disease · score 0.43
- hepatocellular carcinoma · score 0.43
- diastolic blood pressure · score 0.42
- urate measurement · score 0.42
- creatinine measurement · score 0.41
- sex hormone-binding globulin measurement · score 0.41
- monocyte count · score 0.41
- glomerular filtration rate · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27037-F1 | alphafold | PREDICTED | 83.54 | — |
Amino-acid sequence (513 residues)
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL
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