About Adenylate kinase 4, mitochondrial
Adenylate kinase 4, mitochondrial (AK4) is a protein
from Homo sapiens identified by UniProt accession
P27144, 223 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Adenylate kinase 4, mitochondrial |
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| UniProt accession | P27144 |
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| Gene | AK4 |
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| Organism | Homo sapiens |
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| Length | 223 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (97)
Diseases linked to this target (Open Targets).
- platelet crit · score 0.33
- Mental deterioration · score 0.14
- neoplasm · score 0.09
- lung adenocarcinoma · score 0.09
- cancer · score 0.09
- waist-hip ratio · score 0.08
- Gorham-Stout disease · score 0.07
- oral squamous cell carcinoma · score 0.04
- melorheostosis · score 0.04
- eosinophil count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27144-F1 | alphafold | PREDICTED | 91.37 | — |
Amino-acid sequence (223 residues)
MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY
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