Serum paraoxonase/arylesterase 1 (PON1)

About Serum paraoxonase/arylesterase 1

Serum paraoxonase/arylesterase 1 (PON1) is a protein from Homo sapiens identified by UniProt accession P27169, 355 residues long. MolForge cross-references it against 0 known binders and 613 disease associations.

Target properties

Protein name	Serum paraoxonase/arylesterase 1
UniProt accession	P27169
Gene	PON1
Organism	Homo sapiens
Length	355 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (613)

Diseases linked to this target (Open Targets).

amyotrophic lateral sclerosis · score 0.40
aspartate aminotransferase, cytoplasmic measurement · score 0.39
arylesterase enzyme measurement · score 0.38
Amyotrophic lateral sclerosis · score 0.37
leucine carboxyl methyltransferase 1 measurement · score 0.31
blood protein measurement · score 0.31
atopic eczema · score 0.31
metabolite measurement · score 0.31
protein measurement · score 0.30
stem Cell Factor measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P27169-F1	alphafold	PREDICTED	96.78	—

Amino-acid sequence (355 residues)

MAKLIALTLL GMGLALFRNH QSSYQTRLNA LREVQPVELP NCNLVKGIET GSEDLEILPN GLAFISSGLK YPGIKSFNPN SPGKILLMDL NEEDPTVLEL GITGSKFDVS SFNPHGISTF TDEDNAMYLL VVNHPDAKST VELFKFQEEE KSLLHLKTIR HKLLPNLNDI VAVGPEHFYG TNDHYFLDPY LQSWEMYLGL AWSYVVYYSP SEVRVVAEGF DFANGINISP DGKYVYIAEL LAHKIHVYEK HANWTLTPLK SLDFNTLVDN ISVDPETGDL WVGCHPNGMK IFFYDSENPP ASEVLRIQNI LTEEPKVTQV YAENGTVLQG STVASVYKGK LLIGTVFHKA LYCEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards