About 14-3-3 protein theta
14-3-3 protein theta (YWHAQ) is a protein
from Homo sapiens identified by UniProt accession
P27348, 245 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | 14-3-3 protein theta |
|---|
| UniProt accession | P27348 |
|---|
| Gene | YWHAQ |
|---|
| Organism | Homo sapiens |
|---|
| Length | 245 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (137)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- lean body mass · score 0.41
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- fat body mass · score 0.34
- body weight · score 0.33
- base metabolic rate measurement · score 0.27
- whole body water mass · score 0.27
- head and neck squamous cell carcinoma · score 0.27
- gut microbiome measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27348-F1 | alphafold | PREDICTED | 93.46 | — |
Amino-acid sequence (245 residues)
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN
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