Cobalamin binding intrinsic factor (CBLIF)

About Cobalamin binding intrinsic factor

Cobalamin binding intrinsic factor (CBLIF) is a protein from Homo sapiens identified by UniProt accession P27352, 417 residues long. MolForge cross-references it against 0 known binders and 301 disease associations.

Target properties

Protein name	Cobalamin binding intrinsic factor
UniProt accession	P27352
Gene	CBLIF
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (301)

Diseases linked to this target (Open Targets).

Congenital intrinsic factor deficiency · score 0.68
hereditary intrinsic factor deficiency · score 0.64
Gräsbeck-Imerslund disease · score 0.37
gastric carcinoma · score 0.05
sex hormone-binding globulin measurement · score 0.05
body height · score 0.05
dehydrated hereditary stomatocytosis · score 0.05
vitamin B12 measurement · score 0.05
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.05
infection · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P27352-F1	alphafold	PREDICTED	90.51	—

Amino-acid sequence (417 residues)

MAWFALYLLS LLWATAGTST QTQSSCSVPS AQEPLVNGIQ VLMENSVTSS AYPNPSILIA MNLAGAYNLK AQKLLTYQLM SSDNNDLTIG QLGLTIMALT SSCRDPGDKV SILQRQMENW APSSPNAEAS AFYGPSLAIL ALCQKNSEAT LPIAVRFAKT LLANSSPFNV DTGAMATLAL TCMYNKIPVG SEEGYRSLFG QVLKDIVEKI SMKIKDNGII GDIYSTGLAM QALSVTPEPS KKEWNCKKTT DMILNEIKQG KFHNPMSIAQ ILPSLKGKTY LDVPQVTCSP DHEVQPTLPS NPGPGPTSAS NITVIYTINN QLRGVELLFN ETINVSVKSG SVLLVVLEEA QRKNPMFKFE TTMTSWGLVV SSINNIAENV NHKTYWQFLS GVTPLNEGVA DYIPFNHEHI TANFTQY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards