About MAP/microtubule affinity-regulating kinase 3
MAP/microtubule affinity-regulating kinase 3 (MARK3) is a protein
from Homo sapiens identified by UniProt accession
P27448, 753 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | MAP/microtubule affinity-regulating kinase 3 |
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| UniProt accession | P27448 |
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| Gene | MARK3 |
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| Organism | Homo sapiens |
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| Length | 753 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (14)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (131)
Diseases linked to this target (Open Targets).
- cancer · score 0.60
- visual impairment and progressive phthisis bulbi · score 0.55
- Noonan syndrome · score 0.53
- Costello syndrome · score 0.50
- hypertrophic cardiomyopathy · score 0.50
- neurodegenerative disease · score 0.46
- heel bone mineral density · score 0.37
- cardiofaciocutaneous syndrome · score 0.37
- body height · score 0.36
- bone quantitative ultrasound measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27448-F1 | alphafold | PREDICTED | 68.27 | — |
Amino-acid sequence (753 residues)
MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL
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