V-type proton ATPase 16 kDa proteolipid subunit c…

About V-type proton ATPase 16 kDa proteolipid subunit c

V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) is a protein from Homo sapiens identified by UniProt accession P27449, 155 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	V-type proton ATPase 16 kDa proteolipid subunit c
UniProt accession	P27449
Gene	ATP6V0C
Organism	Homo sapiens
Length	155 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
Seizure · score 0.34
childhood-onset epilepsy syndrome · score 0.27
neoplasm · score 0.07
colorectal carcinoma · score 0.05
mean corpuscular hemoglobin concentration · score 0.04
breast carcinoma · score 0.04
cystatin C measurement · score 0.04
body height · score 0.03
mean reticulocyte volume · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P27449-F1	alphafold	PREDICTED	88.53	—

Amino-acid sequence (155 residues)

MSESKSGPEY ASFFAVMGAS AAMVFSALGA AYGTAKSGTG IAAMSVMRPE QIMKSIIPVV MAGIIAIYGL VVAVLIANSL NDDISLYKSF LQLGAGLSVG LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL ILSTK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)