Embryonic growth/differentiation factor 1 (GDF1)

About Embryonic growth/differentiation factor 1

Embryonic growth/differentiation factor 1 (GDF1) is a protein from Homo sapiens identified by UniProt accession P27539, 372 residues long. MolForge cross-references it against 0 known binders and 287 disease associations.

Target properties

Protein name	Embryonic growth/differentiation factor 1
UniProt accession	P27539
Gene	GDF1
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (287)

Diseases linked to this target (Open Targets).

congenital heart defects, multiple types, 6 · score 0.75
right atrial isomerism · score 0.74
Tetralogy of Fallot · score 0.66
Ivemark syndrome · score 0.60
Congenitally uncorrected transposition of the great arteries · score 0.60
Progressive myoclonic epilepsy · score 0.49
conotruncal heart malformations · score 0.46
Heterotaxia · score 0.39
visceral heterotaxy · score 0.38
transposition of the great arteries · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P27539-F1	alphafold	PREDICTED	73.32	—

Amino-acid sequence (372 residues)

MPPPQQGPCG HHLLLLLALL LPSLPLTRAP VPPGPAAALL QALGLRDEPQ GAPRLRPVPP VMWRLFRRRD PQETRSGSRR TSPGVTLQPC HVEELGVAGN IVRHIPDRGA PTRASEPASA AGHCPEWTVV FDLSAVEPAE RPSRARLELR FAAAAAAAPE GGWELSVAQA GQGAGADPGP VLLRQLVPAL GPPVRAELLG AAWARNASWP RSLRLALALR PRAPAACARL AEASLLLVTL DPRLCHPLAR PRRDAEPVLG GGPGGACRAR RLYVSFREVG WHRWVIAPRG FLANYCQGQC ALPVALSGSG GPPALNHAVL RALMHAAAPG AADLPCCVPA RLSPISVLFF DNSDNVVLRQ YEDMVVDECG CR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards