About Aryl hydrocarbon receptor nuclear translocator
Aryl hydrocarbon receptor nuclear translocator (ARNT) is a protein
from Homo sapiens identified by UniProt accession
P27540, 789 residues long.
MolForge cross-references it against 0 known binders and
327 disease associations.
Target properties
| Protein name | Aryl hydrocarbon receptor nuclear translocator |
|---|
| UniProt accession | P27540 |
|---|
| Gene | ARNT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 789 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (327)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- cutaneous melanoma · score 0.39
- Hepatobiliary Neoplasm · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- bile duct carcinoma · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
- breast ductal adenocarcinoma · score 0.37
- hemangioblastoma · score 0.37
- lysosomal storage disease · score 0.35
- Alzheimer disease · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27540-F1 | alphafold | PREDICTED | 55.50 | — |
Amino-acid sequence (789 residues)
MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD DDGEGNSKFL RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN CTDMSNVCQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR SKNQEWLWMR TSSFTFQNPY SDEIEYIICT NTNVKNSSQE PRPTLSNTIQ RPQLGPTANL PLEMGSGQLA PRQQQQQTEL DMVPGRDGLA SYNHSQVVQP VTTTGPEHSK PLEKSDGLFA QDRDPRFSEI YHNINADQSK GISSSTVPAT QQLFSQGNTF PPTPRPAENF RNSGLAPPVT IVQPSASAGQ MLAQISRHSN PTQGATPTWT PTTRSGFSAQ QVATQATAKT RTSQFGVGSF QTPSSFSSMS LPGAPTASPG AAAYPSLTNR GSNFAPETGQ TAGQFQTRTA EGVGVWPQWQ GQQPHHRSSS SEQHVQQPPA QQPGQPEVFQ EMLSMLGDQS NSYNNEEFPD LTMFPPFSE
Explore Aryl hydrocarbon receptor nuclear translocator with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets