About Ceramide synthase 1
Ceramide synthase 1 (CERS1) is a protein
from Homo sapiens identified by UniProt accession
P27544, 350 residues long.
MolForge cross-references it against 0 known binders and
296 disease associations.
Target properties
| Protein name | Ceramide synthase 1 |
|---|
| UniProt accession | P27544 |
|---|
| Gene | CERS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 350 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (296)
Diseases linked to this target (Open Targets).
- Progressive myoclonic epilepsy · score 0.67
- right atrial isomerism · score 0.50
- congenital heart defects, multiple types, 6 · score 0.49
- Heterotaxia · score 0.37
- visceral heterotaxy · score 0.37
- neurodegenerative disease · score 0.37
- Tetralogy of Fallot · score 0.33
- transposition of the great arteries · score 0.33
- genetic disorder · score 0.33
- Heterotaxy · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27544-F1 | alphafold | PREDICTED | 88.36 | — |
Amino-acid sequence (350 residues)
MAAAGPAAGP TGPEPMPSYA QLVQRGWGSA LAAARGCTDC GWGLARRGLA EHAHLAPPEL LLLALGALGW TALRSAATAR LFRPLAKRCC LQPRDAAKMP ESAWKFLFYL GSWSYSAYLL FGTDYPFFHD PPSVFYDWTP GMAVPRDIAA AYLLQGSFYG HSIYATLYMD TWRKDSVVML LHHVVTLILI VSSYAFRYHN VGILVLFLHD ISDVQLEFTK LNIYFKSRGG SYHRLHALAA DLGCLSFGFS WFWFRLYWFP LKVLYATSHC SLRTVPDIPF YFFFNALLLL LTLMNLYWFL YIVAFAAKVL TGQVHELKDL REYDTAEAQS LKPSKAEKPL RNGLVKDKRF
Explore Ceramide synthase 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets