About Replication protein A 70 kDa DNA-binding subunit
Replication protein A 70 kDa DNA-binding subunit (RPA1) is a protein
from Homo sapiens identified by UniProt accession
P27694, 616 residues long.
MolForge cross-references it against 0 known binders and
272 disease associations.
Target properties
| Protein name | Replication protein A 70 kDa DNA-binding subunit |
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| UniProt accession | P27694 |
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| Gene | RPA1 |
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| Organism | Homo sapiens |
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| Length | 616 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (272)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.36
- mean corpuscular hemoglobin concentration · score 0.32
- mean corpuscular hemoglobin · score 0.30
- mean reticulocyte volume · score 0.29
- endometrial cancer · score 0.29
- breast adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- head and neck squamous cell carcinoma · score 0.27
- pancreatic adenocarcinoma · score 0.25
- gastric adenocarcinoma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27694-F1 | alphafold | PREDICTED | 83.80 | — |
Amino-acid sequence (616 residues)
MVGQLSEGAI AAIMQKGDTN IKPILQVINI RPITTGNSPP RYRLLMSDGL NTLSSFMLAT QLNPLVEEEQ LSSNCVCQIH RFIVNTLKDG RRVVILMELE VLKSAEAVGV KIGNPVPYNE GLGQPQVAPP APAASPAASS RPQPQNGSSG MGSTVSKAYG ASKTFGKAAG PSLSHTSGGT QSKVVPIASL TPYQSKWTIC ARVTNKSQIR TWSNSRGEGK LFSLELVDES GEIRATAFNE QVDKFFPLIE VNKVYYFSKG TLKIANKQFT AVKNDYEMTF NNETSVMPCE DDHHLPTVQF DFTGIDDLEN KSKDSLVDII GICKSYEDAT KITVRSNNRE VAKRNIYLMD TSGKVVTATL WGEDADKFDG SRQPVLAIKG ARVSDFGGRS LSVLSSSTII ANPDIPEAYK LRGWFDAEGQ ALDGVSISDL KSGGVGGSNT NWKTLYEVKS ENLGQGDKPD YFSSVATVVY LRKENCMYQA CPTQDCNKKV IDQQNGLYRC EKCDTEFPNF KYRMILSVNI ADFQENQWVT CFQESAEAIL GQNAAYLGEL KDKNEQAFEE VFQNANFRSF IFRVRVKVET YNDESRIKAT VMDVKPVDYR EYGRRLVMSI RRSALM
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