DNA repair nuclease/redox regulator APEX1 (APEX1)

About DNA repair nuclease/redox regulator APEX1

DNA repair nuclease/redox regulator APEX1 (APEX1) is a protein from Homo sapiens identified by UniProt accession P27695, 318 residues long. MolForge cross-references it against 0 known binders and 401 disease associations.

Target properties

Protein name	DNA repair nuclease/redox regulator APEX1
UniProt accession	P27695
Gene	APEX1
Organism	Homo sapiens
Length	318 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (401)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
blood protein measurement · score 0.24
breast adenocarcinoma · score 0.18
cancer · score 0.12
neoplasm · score 0.12
hepatocellular carcinoma · score 0.11
non-small cell lung carcinoma · score 0.11
triple-negative breast cancer · score 0.11
urinary bladder carcinoma · score 0.10
esophageal adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P27695-F1	alphafold	PREDICTED	90.46	—

Amino-acid sequence (318 residues)

MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD QKTSPSGKPA TLKICSWNVD GLRAWIKKKG LDWVKEEAPD ILCLQETKCS ENKLPAELQE LPGLSHQYWS APSDKEGYSG VGLLSRQCPL KVSYGIGDEE HDQEGRVIVA EFDSFVLVTA YVPNAGRGLV RLEYRQRWDE AFRKFLKGLA SRKPLVLCGD LNVAHEEIDL RNPKGNKKNA GFTPQERQGF GELLQAVPLA DSFRHLYPNT PYAYTFWTYM MNARSKNVGW RLDYFLLSHS LLPALCDSKI RSKALGSDHC PITLYLAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards