Deoxycytidine kinase (DCK)

About Deoxycytidine kinase

Deoxycytidine kinase (DCK) is a protein from Homo sapiens identified by UniProt accession P27707, 260 residues long. MolForge cross-references it against 0 known binders and 391 disease associations.

Target properties

Protein name	Deoxycytidine kinase
UniProt accession	P27707
Gene	DCK
Organism	Homo sapiens
Length	260 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (391)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.41
Red cell distribution width · score 0.35
mean corpuscular hemoglobin concentration · score 0.31
viral load · score 0.29
mean reticulocyte volume · score 0.21
triglyceride measurement · score 0.20
telomere length · score 0.16
cutaneous melanoma · score 0.12
urate measurement · score 0.12
bone density · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P27707-F1	alphafold	PREDICTED	88.44	—

Amino-acid sequence (260 residues)

MATPPKRSCP SFSASSEGTR IKKISIEGNI AAGKSTFVNI LKQLCEDWEV VPEPVARWCN VQSTQDEFEE LTMSQKNGGN VLQMMYEKPE RWSFTFQTYA CLSRIRAQLA SLNGKLKDAE KPVLFFERSV YSDRYIFASN LYESECMNET EWTIYQDWHD WMNNQFGQSL ELDGIIYLQA TPETCLHRIY LRGRNEEQGI PLEYLEKLHY KHESWLLHRT LKTNFDYLQE VPILTLDVNE DFKDKYESLV EKVKEFLSTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards