About Calreticulin
Calreticulin (CALR) is a protein
from Homo sapiens identified by UniProt accession
P27797, 417 residues long.
MolForge cross-references it against 0 known binders and
788 disease associations.
Target properties
| Protein name | Calreticulin |
|---|
| UniProt accession | P27797 |
|---|
| Gene | CALR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 417 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (788)
Diseases linked to this target (Open Targets).
- platelet count · score 0.60
- neoplasm · score 0.58
- essential thrombocythemia · score 0.58
- platelet crit · score 0.56
- reticulocyte measurement · score 0.55
- erythrocyte count · score 0.55
- Red cell distribution width · score 0.54
- neurodegenerative disease · score 0.52
- hemoglobin measurement · score 0.51
- hemorrhagic disease · score 0.51
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27797-F1 | alphafold | PREDICTED | 89.12 | — |
Amino-acid sequence (417 residues)
MLLSVPLLLG LLGLAVAEPA VYFKEQFLDG DGWTSRWIES KHKSDFGKFV LSSGKFYGDE EKDKGLQTSQ DARFYALSAS FEPFSNKGQT LVVQFTVKHE QNIDCGGGYV KLFPNSLDQT DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDASKPEDWD ERAKIDDPTD SKPEDWDKPE HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS PDPSIYAYDN FGVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KAAEKQMKDK QDEEQRLKEE EEDKKRKEEE EAEDKEDDED KDEDEEDEED KEEDEEEDVP GQAKDEL
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