Interleukin-1 receptor type 2 (IL1R2)

About Interleukin-1 receptor type 2

Interleukin-1 receptor type 2 (IL1R2) is a protein from Homo sapiens identified by UniProt accession P27930, 398 residues long. MolForge cross-references it against 0 known binders and 243 disease associations.

Target properties

Protein name	Interleukin-1 receptor type 2
UniProt accession	P27930
Gene	IL1R2
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (243)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.45
ST2 protein measurement · score 0.42
neutrophil count · score 0.28
inflammatory bowel disease · score 0.27
eosinophil count · score 0.25
ulcerative colitis · score 0.23
protein measurement · score 0.12
breast adenocarcinoma · score 0.10
myeloid white cell count · score 0.08
coronary artery disease · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P27930-F1	alphafold	PREDICTED	83.77	—

Amino-acid sequence (398 residues)

MLRLYVLVMG VSAFTLQPAA HTGAARSCRF RGRHYKREFR LEGEPVALRC PQVPYWLWAS VSPRINLTWH KNDSARTVPG EEETRMWAQD GALWLLPALQ EDSGTYVCTT RNASYCDKMS IELRVFENTD AFLPFISYPQ ILTLSTSGVL VCPDLSEFTR DKTDVKIQWY KDSLLLDKDN EKFLSVRGTT HLLVHDVALE DAGYYRCVLT FAHEGQQYNI TRSIELRIKK KKEETIPVII SPLKTISASL GSRLTIPCKV FLGTGTPLTT MLWWTANDTH IESAYPGGRV TEGPRQEYSE NNENYIEVPL IFDPVTREDL HMDFKCVVHN TLSFQTLRTT VKEASSTFSW GIVLAPLSLA FLVLGGIWMH RRCKHRTGKA DGLTVLWPHH QDFQSYPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards