About Acyloxyacyl hydrolase
Acyloxyacyl hydrolase (AOAH) is a protein
from Homo sapiens identified by UniProt accession
P28039, 575 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Acyloxyacyl hydrolase |
|---|
| UniProt accession | P28039 |
|---|
| Gene | AOAH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 575 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.31
- bone density · score 0.31
- type 2 diabetes mellitus · score 0.30
- arterial stiffness measurement · score 0.17
- body mass index · score 0.09
- body weight · score 0.09
- antisocial behaviour measurement · score 0.07
- substance abuse · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- sitting height measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28039-F1 | alphafold | PREDICTED | 90.35 | — |
Amino-acid sequence (575 residues)
MQSPWKILTV APLFLLLSLQ SSASPANDDQ SRPSLSNGHT CVGCVLVVSV IEQLAQVHNS TVQASMERLC SYLPEKLFLK TTCYLVIDKF GSDIIKLLSA DMNADVVCHT LEFCKQNTGQ PLCHLYPLPK ETWKFTLQKA RQIVKKSPIL KYSRSGSDIC SLPVLAKICQ KIKLAMEQSV PFKDVDSDKY SVFPTLRGYH WRGRDCNDSD ESVYPGRRPN NWDVHQDSNC NGIWGVDPKD GVPYEKKFCE GSQPRGIILL GDSAGAHFHI SPEWITASQM SLNSFINLPT ALTNELDWPQ LSGATGFLDS TVGIKEKSIY LRLWKRNHCN HRDYQNISRN GASSRNLKKF IESLSRNKVL DYPAIVIYAM IGNDVCSGKS DPVPAMTTPE KLYSNVMQTL KHLNSHLPNG SHVILYGLPD GTFLWDNLHN RYHPLGQLNK DMTYAQLYSF LNCLQVSPCH GWMSSNKTLR TLTSERAEQL SNTLKKIAAS EKFTNFNLFY MDFAFHEIIQ EWQKRGGQPW QLIEPVDGFH PNEVALLLLA DHFWKKVQLQ WPQILGKENP FNPQIKQVFG DQGGH
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