Proteasome subunit beta type-8 (PSMB8)

About Proteasome subunit beta type-8

Proteasome subunit beta type-8 (PSMB8) is a protein from Homo sapiens identified by UniProt accession P28062, 276 residues long. MolForge cross-references it against 0 known binders and 320 disease associations.

Target properties

Protein name	Proteasome subunit beta type-8
UniProt accession	P28062
Gene	PSMB8
Organism	Homo sapiens
Length	276 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (320)

Diseases linked to this target (Open Targets).

Proteasome disability syndrome · score 0.79
proteosome-associated autoinflammatory syndrome · score 0.76
HIV infection · score 0.46
glioblastoma multiforme · score 0.37
autoinflammatory syndrome · score 0.34
breast adenocarcinoma · score 0.30
esophageal cancer · score 0.28
urinary bladder cancer · score 0.28
head and neck squamous cell carcinoma · score 0.28
squamous cell lung carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28062-F1	alphafold	PREDICTED	83.81	—

Amino-acid sequence (276 residues)

MALLDVCGAP RGQRPESALP VAGSGRRSDP GHYSFSMRSP ELALPRGMQP TEFFQSLGGD GERNVQIEMA HGTTTLAFKF QHGVIAAVDS RASAGSYISA LRVNKVIEIN PYLLGTMSGC AADCQYWERL LAKECRLYYL RNGERISVSA ASKLLSNMMC QYRGMGLSMG SMICGWDKKG PGLYYVDEHG TRLSGNMFST GSGNTYAYGV MDSGYRPNLS PEEAYDLGRR AIAYATHRDS YSGGVVNMYH MKEDGWVKVE STDVSDLLHQ YREANQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards