About Proteasome subunit alpha type-5
Proteasome subunit alpha type-5 (PSMA5) is a protein
from Homo sapiens identified by UniProt accession
P28066, 241 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Proteasome subunit alpha type-5 |
|---|
| UniProt accession | P28066 |
|---|
| Gene | PSMA5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 241 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (97)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- glioblastoma multiforme · score 0.37
- breast adenocarcinoma · score 0.30
- squamous cell lung carcinoma · score 0.28
- neurodegenerative disease · score 0.16
- chronotype measurement · score 0.13
- apolipoprotein B measurement · score 0.11
- intelligence · score 0.10
- multiple myeloma · score 0.10
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28066-F1 | alphafold | PREDICTED | 94.14 | — |
Amino-acid sequence (241 residues)
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGI QTSEGVCLAV EKRITSPLME PSSIEKIVEI DAHIGCAMSG LIADAKTLID KARVETQNHW FTYNETMTVE SVTQAVSNLA LQFGEEDADP GAMSRPFGVA LLFGGVDEKG PQLFHMDPSG TFVQCDARAI GSASEGAQSS LQEVYHKSMT LKEAIKSSLI ILKQVMEEKL NATNIELATV QPGQNFHMFT KEELEEVIKD I
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