About HLA class II histocompatibility antigen, DM beta chain
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) is a protein
from Homo sapiens identified by UniProt accession
P28068, 263 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | HLA class II histocompatibility antigen, DM beta chain |
|---|
| UniProt accession | P28068 |
|---|
| Gene | HLA-DMB |
|---|
| Organism | Homo sapiens |
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| Length | 263 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (132)
Diseases linked to this target (Open Targets).
- Iridocyclitis · score 0.33
- reactive arthritis · score 0.31
- ankylosing spondylitis · score 0.31
- ciliary body disorder · score 0.25
- corneal disease · score 0.25
- scleral disorder · score 0.25
- spondyloarthropathy · score 0.25
- iris disorder · score 0.25
- rheumatic disease · score 0.25
- type 1 diabetes mellitus · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28068-F1 | alphafold | PREDICTED | 89.20 | — |
Amino-acid sequence (263 residues)
MITFLPLLLG LSLGCTGAGG FVAHVESTCL LDDAGTPKDF TYCISFNKDL LTCWDPEENK MAPCEFGVLN SLANVLSQHL NQKDTLMQRL RNGLQNCATH TQPFWGSLTN RTRPPSVQVA KTTPFNTREP VMLACYVWGF YPAEVTITWR KNGKLVMPHS SAHKTAQPNG DWTYQTLSHL ALTPSYGDTY TCVVEHTGAP EPILRDWTPG LSPMQTLKVS VSAVTLGLGL IIFSLGVISW RRAGHSSYTP LPGSNYSEGW HIS
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