About Pituitary-specific positive transcription factor 1
Pituitary-specific positive transcription factor 1 (POU1F1) is a protein
from Homo sapiens identified by UniProt accession
P28069, 291 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Pituitary-specific positive transcription factor 1 |
|---|
| UniProt accession | P28069 |
|---|
| Gene | POU1F1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 291 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (97)
Diseases linked to this target (Open Targets).
- pituitary hormone deficiency, combined, 1 · score 0.82
- Combined pituitary hormone deficiencies, genetic forms · score 0.78
- combined pituitary hormone deficiencies, genetic form · score 0.43
- body height · score 0.41
- genetic disorder · score 0.41
- isolated growth hormone deficiency type II · score 0.38
- congenital hypothyroidism · score 0.37
- hypothyroidism due to deficient transcription factors involved in pituitary development or function · score 0.37
- prostate carcinoma · score 0.35
- brain connectivity measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28069-F1 | alphafold | PREDICTED | 67.73 | — |
Amino-acid sequence (291 residues)
MSCQAFTSAD TFIPLNSDAS ATLPLIMHHS AAECLPVSNH ATNVMSTATG LHYSVPSCHY GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPIHQPLLAE DPTAADFKQE LRRKSKLVEE PIDMDSPEIR ELEKFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF KNACKLKAIL SKWLEEAEQV GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEQNKPS SQEIMRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FSISKEHLEC R
Explore Pituitary-specific positive transcription factor 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets