Proteasome subunit beta type-4 (PSMB4)

About Proteasome subunit beta type-4

Proteasome subunit beta type-4 (PSMB4) is a protein from Homo sapiens identified by UniProt accession P28070, 264 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Proteasome subunit beta type-4
UniProt accession	P28070
Gene	PSMB4
Organism	Homo sapiens
Length	264 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

proteasome-associated autoinflammatory syndrome 3 · score 0.58
HIV infection · score 0.46
proteosome-associated autoinflammatory syndrome · score 0.34
Proteasome disability syndrome · score 0.33
ovarian cancer · score 0.29
endometrial cancer · score 0.29
lung adenocarcinoma · score 0.28
glioblastoma multiforme · score 0.28
squamous cell lung carcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28070-F1	alphafold	PREDICTED	87.42	—

Amino-acid sequence (264 residues)

MEAFLGSRSG LWAGGPAPGQ FYRIPSTPDS FMDPASALYR GPITRTQNPM VTGTSVLGVK FEGGVVIAAD MLGSYGSLAR FRNISRIMRV NNSTMLGASG DYADFQYLKQ VLGQMVIDEE LLGDGHSYSP RAIHSWLTRA MYSRRSKMNP LWNTMVIGGY ADGESFLGYV DMLGVAYEAP SLATGYGAYL AQPLLREVLE KQPVLSQTEA RDLVERCMRV LYYRDARSYN RFQIATVTEK GVEIEGPLST ETNWDIAHMI SGFE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards