Proteasome subunit beta type-6 (PSMB6)

About Proteasome subunit beta type-6

Proteasome subunit beta type-6 (PSMB6) is a protein from Homo sapiens identified by UniProt accession P28072, 239 residues long. MolForge cross-references it against 0 known binders and 100 disease associations.

Target properties

Protein name	Proteasome subunit beta type-6
UniProt accession	P28072
Gene	PSMB6
Organism	Homo sapiens
Length	239 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (100)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
neurodegenerative disease · score 0.37
breast adenocarcinoma · score 0.30
ovarian cancer · score 0.29
endometrial cancer · score 0.29
lung adenocarcinoma · score 0.29
esophageal cancer · score 0.28
urinary bladder cancer · score 0.28
glioblastoma multiforme · score 0.28
head and neck squamous cell carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28072-F1	alphafold	PREDICTED	88.71	—

Amino-acid sequence (239 residues)

MAATLLAARG AGPAPAWGPE AFTPDWESRE VSTGTTIMAV QFDGGVVLGA DSRTTTGSYI ANRVTDKLTP IHDRIFCCRS GSAADTQAVA DAVTYQLGFH SIELNEPPLV HTAASLFKEM CYRYREDLMA GIIIAGWDPQ EGGQVYSVPM GGMMVRQSFA IGGSGSSYIY GYVDATYREG MTKEECLQFT ANALALAMER DGSSGGVIRL AAIAESGVER QVLLGDQIPK FAVATLPPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards