About Glutathione S-transferase Mu 2
Glutathione S-transferase Mu 2 (GSTM2) is a protein
from Homo sapiens identified by UniProt accession
P28161, 218 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Glutathione S-transferase Mu 2 |
|---|
| UniProt accession | P28161 |
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| Gene | GSTM2 |
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| Organism | Homo sapiens |
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| Length | 218 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (145)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- eye morphology measurement · score 0.24
- platelet count · score 0.23
- sex hormone-binding globulin measurement · score 0.21
- mean platelet volume · score 0.14
- apolipoprotein B measurement · score 0.14
- blood protein measurement · score 0.14
- urinary bladder cancer · score 0.13
- bilirubin measurement · score 0.09
- apolipoprotein A 1 measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28161-F1 | alphafold | PREDICTED | 98.51 | — |
Amino-acid sequence (218 residues)
MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEG LEKISAYMKS SRFLPRPVFT KMAVWGNK
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