About ATP-binding cassette sub-family D member 3
ATP-binding cassette sub-family D member 3 (ABCD3) is a protein
from Homo sapiens identified by UniProt accession
P28288, 659 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | ATP-binding cassette sub-family D member 3 |
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| UniProt accession | P28288 |
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| Gene | ABCD3 |
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| Organism | Homo sapiens |
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| Length | 659 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (66)
Diseases linked to this target (Open Targets).
- congenital bile acid synthesis defect 5 · score 0.45
- Congenital bile acid synthesis defect type 1 · score 0.37
- platelet count · score 0.31
- platelet component distribution width · score 0.29
- appendicular lean mass · score 0.24
- mean platelet volume · score 0.14
- cutaneous melanoma · score 0.13
- creatinine measurement · score 0.12
- tissue factor measurement · score 0.11
- platelet crit · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28288-F1 | alphafold | PREDICTED | 82.90 | — |
Amino-acid sequence (659 residues)
MAAFSKYLTA RNSSLAGAAF LLLCLLHKRR RALGLHGKKS GKPPLQNNEK EGKKERAVVD KVFFSRLIQI LKIMVPRTFC KETGYLVLIA VMLVSRTYCD VWMIQNGTLI ESGIIGRSRK DFKRYLLNFI AAMPLISLVN NFLKYGLNEL KLCFRVRLTK YLYEEYLQAF TYYKMGNLDN RIANPDQLLT QDVEKFCNSV VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLVVS GLFLTRLRRP IGKMTITEQK YEGEYRYVNS RLITNSEEIA FYNGNKREKQ TVHSVFRKLV EHLHNFILFR FSMGFIDSII AKYLATVVGY LVVSRPFLDL SHPRHLKSTH SELLEDYYQS GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD LNHGKYERTM VSQQEKGIEG VQVIPLIPGA GEIIIADNII KFDHVPLATP NGDVLIRDLN FEVRSGANVL ICGPNGCGKS SLFRVLGELW PLFGGRLTKP ERGKLFYVPQ RPYMTLGTLR DQVIYPDGRE DQKRKGISDL VLKEYLDNVQ LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA VSVDVEGYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKQI TEDTVEFGS
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