About Protein-lysine 6-oxidase
Protein-lysine 6-oxidase (LOX) is a protein
from Homo sapiens identified by UniProt accession
P28300, 417 residues long.
MolForge cross-references it against 0 known binders and
652 disease associations.
Target properties
| Protein name | Protein-lysine 6-oxidase |
|---|
| UniProt accession | P28300 |
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| Gene | LOX |
|---|
| Organism | Homo sapiens |
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| Length | 417 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (652)
Diseases linked to this target (Open Targets).
- familial thoracic aortic aneurysm and aortic dissection · score 0.75
- aortic aneurysm · score 0.61
- Abnormality of the cardiovascular system · score 0.52
- Aortic dissection · score 0.50
- marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections · score 0.50
- FEV/FVC ratio · score 0.45
- vital capacity · score 0.37
- Inguinal hernia · score 0.36
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.35
- keratoconus · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28300-F1 | alphafold | PREDICTED | 67.40 | — |
Amino-acid sequence (417 residues)
MRFAWTVLLL GPLQLCALVH CAPPAAGQQQ PPREPPAAPG AWRQQIQWEN NGQVFSLLSL GSQYQPQRRR DPGAAVPGAA NASAQQPRTP ILLIRDNRTA AARTRTAGSS GVTAGRPRPT ARHWFQAGYS TSRAREAGAS RAENQTAPGE VPALSNLRPP SRVDGMVGDD PYNPYKYSDD NPYYNYYDTY ERPRPGGRYR PGYGTGYFQY GLPDLVADPY YIQASTYVQK MSMYNLRCAA EENCLASTAY RADVRDYDHR VLLRFPQRVK NQGTSDFLPS RPRYSWEWHS CHQHYHSMDE FSHYDLLDAN TQRRVAEGHK ASFCLEDTSC DYGYHRRFAC TAHTQGLSPG CYDTYGADID CQWIDITDVK PGNYILKVSV NPSYLVPESD YTNNVVRCDI RYTGHHAYAS GCTISPY
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