ETS domain-containing protein Elk-4 (ELK4)

About ETS domain-containing protein Elk-4

ETS domain-containing protein Elk-4 (ELK4) is a protein from Homo sapiens identified by UniProt accession P28324, 431 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	ETS domain-containing protein Elk-4
UniProt accession	P28324
Gene	ELK4
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

bile duct carcinoma · score 0.37
prostate adenocarcinoma · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
skin basal cell carcinoma · score 0.37
neurodegenerative disease · score 0.37
hepatocellular carcinoma · score 0.29
melanoma · score 0.29
esophageal squamous cell carcinoma · score 0.28
urinary bladder carcinoma · score 0.28
pancreatic ductal adenocarcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28324-F1	alphafold	PREDICTED	59.03	—

Amino-acid sequence (431 residues)

MDSAITLWQF LLQLLQKPQN KHMICWTSND GQFKLLQAEE VARLWGIRKN KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LNMDPMTVGR IEGDCESLNF SEVSSSSKDV ENGGKDKPPQ PGAKTSSRND YIHSGLYSSF TLNSLNSSNV KLFKLIKTEN PAEKLAEKKS PQEPTPSVIK FVTTPSKKPP VEPVAATISI GPSISPSSEE TIQALETLVS PKLPSLEAPT SASNVMTAFA TTPPISSIPP LQEPPRTPSP PLSSHPDIDT DIDSVASQPM ELPENLSLEP KDQDSVLLEK DKVNNSSRSK KPKGLELAPT LVITSSDPSP LGILSPSLPT ASLTPAFFSQ TPIILTPSPL LSSIHFWSTL SPVAPLSPAR LQGANTLFQF PSVLNSHGPF TLSGLDGPST PGPFSPDLQK T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards