About Cystatin-D
Cystatin-D (CST5) is a protein
from Homo sapiens identified by UniProt accession
P28325, 142 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Cystatin-D |
|---|
| UniProt accession | P28325 |
|---|
| Gene | CST5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 142 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- cystatin-D measurement · score 0.34
- protein measurement · score 0.19
- pacman dysplasia · score 0.07
- Intermediate osteopetrosis · score 0.05
- autosomal recessive osteopetrosis 6 · score 0.05
- Hypocalcemic vitamin D-resistant rickets · score 0.05
- hip dysplasia, Beukes type · score 0.05
- gnathodiaphyseal dysplasia · score 0.05
- Eiken syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28325-F1 | alphafold | PREDICTED | 87.78 | — |
Amino-acid sequence (142 residues)
MMWPMHTPLL LLTALMVAVA GSASAQSRTL AGGIHATDLN DKSVQCALDF AISEYNKVIN KDEYYSRPLQ VMAAYQQIVG GVNYYFNVKF GRTTCTKSQP NLDNCPFNDQ PKLKEEEFCS FQINEVPWED KISILNYKCR KV
Explore Cystatin-D with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets