Peroxisome biogenesis factor 2 (PEX2)

About Peroxisome biogenesis factor 2

Peroxisome biogenesis factor 2 (PEX2) is a protein from Homo sapiens identified by UniProt accession P28328, 305 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Peroxisome biogenesis factor 2
UniProt accession	P28328
Gene	PEX2
Organism	Homo sapiens
Length	305 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 5A (Zellweger) · score 0.76
Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.75
Zellweger syndrome · score 0.70
peroxisome biogenesis disorder · score 0.65
Zellweger spectrum disorders · score 0.52
testosterone measurement · score 0.42
genetic disorder · score 0.41
peroxisome biogenesis disorder, complementation group 7 · score 0.37
peroxisome biogenesis disorder type 3B · score 0.37
age at menarche · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28328-F1	alphafold	PREDICTED	80.38	—

Amino-acid sequence (305 residues)

MASRKENAKS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKACL WVFLWRFTIY SKNATVGQSV LNIKYKNDFS PNLRYQPPSK NQKIWYAVCT IGGRWLEERC YDLFRNHHLA SFGKVKQCVN FVIGLLKLGG LINFLIFLQR GKFATLTERL LGIHSVFCKP QNICEVGFEY MNRELLWHGF AEFLIFLLPL INVQKLKAKL SSWCIPLTGA PNSDNTLATS GKECALCGEW PTMPHTIGCE HIFCYFCAKS SFLFDVYFTC PKCGTEVHSL QPLKSGIEMS EVNAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards