About Choline O-acetyltransferase
Choline O-acetyltransferase (CHAT) is a protein
from Homo sapiens identified by UniProt accession
P28329, 748 residues long.
MolForge cross-references it against 0 known binders and
324 disease associations.
Target properties
| Protein name | Choline O-acetyltransferase |
|---|
| UniProt accession | P28329 |
|---|
| Gene | CHAT |
|---|
| Organism | Homo sapiens |
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| Length | 748 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (324)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.81
- Presynaptic congenital myasthenic syndromes · score 0.73
- congenital myasthenic syndrome · score 0.52
- Respiratory insufficiency · score 0.43
- Pneumonia, Aspiration · score 0.43
- Febrile seizure (within the age range of 3 months to 6 years) · score 0.43
- Decreased activity of the pyruvate dehydrogenase complex · score 0.43
- lactic acidosis · score 0.43
- External ophthalmoplegia · score 0.43
- flatfoot · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28329-F1 | alphafold | PREDICTED | 83.91 | — |
Amino-acid sequence (748 residues)
MGLRTAKKRG LGGGGKWKRE EGGGTRGRRE VRPACFLQSG GRGDPGDVGG PAGNPGCSPH PRAATRPPPL PAHTPAHTPE WCGAASAEAA EPRRAGPHLC IPAPGLTKTP ILEKVPRKMA AKTPSSEESG LPKLPVPPLQ QTLATYLQCM RHLVSEEQFR KSQAIVQQFG APGGLGETLQ QKLLERQEKT ANWVSEYWLN DMYLNNRLAL PVNSSPAVIF ARQHFPGTDD QLRFAASLIS GVLSYKALLD SHSIPTDCAK GQLSGQPLCM KQYYGLFSSY RLPGHTQDTL VAQNSSIMPE PEHVIVACCN QFFVLDVVIN FRRLSEGDLF TQLRKIVKMA SNEDERLPPI GLLTSDGRSE WAEARTVLVK DSTNRDSLDM IERCICLVCL DAPGGVELSD THRALQLLHG GGYSKNGANR WYDKSLQFVV GRDGTCGVVC EHSPFDGIVL VQCTEHLLKH VTQSSRKLIR ADSVSELPAP RRLRWKCSPE IQGHLASSAE KLQRIVKNLD FIVYKFDNYG KTFIKKQKCS PDAFIQVALQ LAFYRLHRRL VPTYESASIR RFQEGRVDNI RSATPEALAF VRAVTDHKAA VPASEKLLLL KDAIRAQTAY TVMAITGMAI DNHLLALREL ARAMCKELPE MFMDETYLMS NRFVLSTSQV PTTTEMFCCY GPVVPNGYGA CYNPQPETIL FCISSFHSCK ETSSSKFAKA VEESLIDMRD LCSLLPPTES KPLATKEKAT RPSQGHQP
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