About Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL) is a protein
from Homo sapiens identified by UniProt accession
P28330, 430 residues long.
MolForge cross-references it against 0 known binders and
130 disease associations.
Target properties
| Protein name | Long-chain specific acyl-CoA dehydrogenase, mitochondrial |
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| UniProt accession | P28330 |
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| Gene | ACADL |
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| Organism | Homo sapiens |
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| Length | 430 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (130)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.44
- serum metabolite measurement · score 0.39
- metabolite measurement · score 0.39
- acylcarnitine measurement · score 0.31
- blood metabolite measurement · score 0.31
- insomnia · score 0.23
- total blood protein measurement · score 0.23
- very long chain acyl-CoA dehydrogenase deficiency · score 0.16
- long chain acyl-CoA dehydrogenase deficiency · score 0.15
- body height · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28330-F1 | alphafold | PREDICTED | 92.83 | — |
Amino-acid sequence (430 residues)
MAARLLRGSL RVLGGHRAPR QLPAARCSHS GGEERLETPS AKKLTDIGIR RIFSPEHDIF RKSVRKFFQE EVIPHHSEWE KAGEVSREVW EKAGKQGLLG VNIAEHLGGI GGDLYSAAIV WEEQAYSNCS GPGFSIHSGI VMSYITNHGS EEQIKHFIPQ MTAGKCIGAI AMTEPGAGSD LQGIKTNAKK DGSDWILNGS KVFISNGSLS DVVIVVAVTN HEAPSPAHGI SLFLVENGMK GFIKGRKLHK MGLKAQDTAE LFFEDIRLPA SALLGEENKG FYYIMKELPQ ERLLIADVAI SASEFMFEET RNYVKQRKAF GKTVAHLQTV QHKLAELKTH ICVTRAFVDN CLQLHEAKRL DSATACMAKY WASELQNSVA YDCVQLHGGW GYMWEYPIAK AYVDARVQPI YGGTNEIMKE LIAREIVFDK
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